How urbanization unfolds in the text few decades and which urban development path we choose are potentially critical to the efforts aimed at stabilizing greenhouse gas emissions. However, our understanding of urban, as a unit or system, and its cross-scale linkages in the context of carbon management is at infancy state. In this context, this article outlines, the key challenges and introduces a new scientific initiative - Urban and Regional Carbon Management Initiative of the Global Carbon Project, which has raised key scientific questions with the aim to find reasonable answers. This article mainly showcases key science questions, past activities and future outlook with the aim to reach out to the related scientific and policy communities.